;In vivo: MK-4827 is properly tolerated in vivo and demonstrates efficacy as a single agent in a very xenograft model of BRCA-1 deficient cancer [1]. On top of that, MK-4827 strongly improves the impact of radiation on a number of human tumor xenografts, each p53 wild form and p53 mutant. The improvement of radiation response is observed in clinica

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